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7.2.1.1 Melatonin Melatonin, a neurohormone that regulates circadian rhythms, has been shown to have protective effects on the BBB in models of I/R injury (Zhang et al., 2024b)

[DOI] [PubMed] [Google Scholar] 19.Akhavan O

Subsequently, Moore proposed the hypothesis that intestinal secretions might have a glycemic-lowering effect in diabetics, which was the first study to suggest an effect of intestinal secretions on blood glucose (Moore, 1906), and in the 1960s a team of researchers in the UK and the US independently discovered the incretin effect, in which oral glucose markedly stimulates insulin secretion, setting the stage for the subsequent development of incretin (McIntyre et al., 1964)

Insulin and glucagon regulation of glutathione S-transferase expression in primary cultured rat hepatocytes

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